InnateDB Protein
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IDBP-226982.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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CR1
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Protein Name
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complement component (3b/4b) receptor 1 (Knops blood group)
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Synonyms
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C3BR; C4BR; CD35; KN;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000383744
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InnateDB Gene
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IDBG-106358 (CR1)
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Protein Structure
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Function |
Mediates cellular binding of particles and immune complexes that have activated complement.
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Subcellular Localization |
Membrane; Single-pass type I membrane protein.
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Disease Associations |
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Tissue Specificity |
Present on erythrocytes, leukocytes, glomerular podocytes, and splenic follicular dendritic cells.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
4
[view]
|
Protein-Protein |
4
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0001851
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complement component C3b binding
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GO:0001855
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complement component C4b binding
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GO:0001861
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complement component C4b receptor activity
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GO:0004877
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complement component C3b receptor activity
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Biological Process |
GO:0002430
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complement receptor mediated signaling pathway
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GO:0006958
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complement activation, classical pathway
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GO:0030449
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regulation of complement activation
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GO:0045087
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innate immune response
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GO:0045957
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negative regulation of complement activation, alternative pathway
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GO:0045959
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negative regulation of complement activation, classical pathway
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GO:1900004
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negative regulation of serine-type endopeptidase activity
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GO:1900005
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positive regulation of serine-type endopeptidase activity
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Cellular Component |
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PDB ID |
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InterPro |
IPR000436
Sushi/SCR/CCP
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PFAM |
PF00084
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PRINTS |
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PIRSF |
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SMART |
SM00032
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TIGRFAMs |
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Modification |
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SwissProt |
P17927
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PhosphoSite |
PhosphoSite-P17927
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TrEMBL |
Q9UQR7
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UniProt Splice Variant |
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Entrez Gene |
1378
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UniGene |
Hs.334019
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RefSeq |
NP_000564
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HUGO |
HGNC:2334
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OMIM |
120620
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CCDS |
CCDS44309
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HPRD |
00398
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IMGT |
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EMBL |
AF264715
AK298486
AL137789
AL691452
L17390
L17391
L17392
L17393
L17394
L17395
L17396
L17397
L17398
L17399
L17400
L17401
L17402
L17403
L17404
L17405
L17406
L17407
L17408
L17409
L17410
L17411
L17412
L17413
L17414
L17415
L17416
L17417
L17418
L17419
L17420
L17421
L17422
L17423
L17424
L17425
L17426
L17427
L17428
L17429
L17430
M11569
M11617
M11618
M31238
M31239
M31240
M31241
X05309
X14362
Y00816
|
GenPept |
AAA52297
AAA52298
AAA52299
AAB60694
AAB60695
AAD15289
AAG14442
BAG60695
CAA28933
CAA32541
CAA68755
CAI16042
CAI16043
CAI16723
CAI16725
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