InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: VAMP1

Summary

InnateDB Protein

IDBP-227107.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

VAMP1

Protein Name

vesicle-associated membrane protein 1 (synaptobrevin 1)

Synonyms

SPAX1; SYB1; VAMP-1;

Species

Homo sapiens

Ensembl Protein

ENSP00000383702

InnateDB Gene

IDBG-14084 (VAMP1)

Protein Structure

UniProt Annotation

Function

Involved in the targeting and/or fusion of transport vesicles to their target membrane.

Subcellular Localization

Isoform 1: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250}; Single-pass type IV membrane protein {ECO:0000250}. Cell junction, synapse, synaptosome {ECO:0000250}.Isoform 2: Cytoplasmic vesicle membrane {ECO:0000250}; Single-pass type IV membrane protein {ECO:0000250}. Cell junction, synapse, synaptosome {ECO:0000250}.Isoform 3: Mitochondrion outer membrane; Single-pass type IV membrane protein.

Disease Associations

Tissue Specificity

Nervous system, skeletal muscle and adipose tissue.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.

Experimentally validated
Total	12 [view]
Protein-Protein	8 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0007268	synaptic transmission
GO:0007269	neurotransmitter secretion
GO:0016192	vesicle-mediated transport

Cellular Component

GO:0005741	mitochondrial outer membrane
GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane
GO:0030054	cell junction
GO:0030666	endocytic vesicle membrane
GO:0030672	synaptic vesicle membrane
GO:0043005	neuron projection