Version 5.4
Homo sapiens Protein: ZG16
Summary
InnateDB Protein IDBP-227523.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ZG16
Protein Name zymogen granule protein 16 homolog (rat)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000383563
InnateDB Gene IDBG-24597 (ZG16)
Protein Structure
UniProt Annotation
Function May play a role in protein trafficking. May act as a linker molecule between the submembranous matrix on the luminal side of zymogen granule membrane (ZGM) and aggregated secretory proteins during granule formation in the TGN. {ECO:0000269PubMed:17307141}.
Subcellular Localization Secreted, extracellular space, extracellular matrix {ECO:0000269PubMed:17307141}. Cytoplasmic vesicle lumen {ECO:0000305PubMed:17307141}. Golgi apparatus lumen {ECO:0000269PubMed:17307141}. Note=Stored in zymogen granules. {ECO:0000250}.
Disease Associations
Tissue Specificity Highly expressed in liver. Detected at lower levels in colon, ileum and jejunum. {ECO:0000269PubMed:17307141}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005529 sugar binding
Biological Process
GO:0015031 protein transport
Cellular Component
GO:0005576 extracellular region
GO:0005578 proteinaceous extracellular matrix
GO:0005796 Golgi lumen
GO:0031012 extracellular matrix
GO:0042589 zymogen granule membrane
GO:0060205 cytoplasmic membrane-bounded vesicle lumen
Protein Structure and Domains
PDB ID
InterPro IPR001229 Mannose-binding lectin
PFAM PF01419
PRINTS
PIRSF
SMART SM00915
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O60844
PhosphoSite PhosphoSite-O60844
TrEMBL
UniProt Splice Variant
Entrez Gene 653808
UniGene Hs.632195
RefSeq NP_689551
HUGO HGNC:30961
OMIM
CCDS CCDS54000
HPRD
IMGT
EMBL AB092813 AC002301 AC009133 AK125559 AK312002 BC029149 BC150656 CH471238
GenPept AAC08708 AAH29149 AAI50657 BAC20361 BAG34940 BAG54214 EAW80011

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca