InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SAMSN1

Summary

InnateDB Protein

IDBP-227926.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SAMSN1

Protein Name

SAM domain, SH3 domain and nuclear localization signals 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000383411

InnateDB Gene

IDBG-762 (SAMSN1)

Protein Structure

UniProt Annotation

Function

Negative regulator of B-cell activation. Down-regulates cell proliferation (in vitro). Promotes RAC1-dependent membrane ruffle formation and reorganization of the actin cytoskeleton. Regulates cell spreading and cell polarization. Stimulates HDAC1 activity. Regulates LYN activity by modulating its tyrosine phosphorylation (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:11594764}. Cytoplasm {ECO:0000250}. Cell projection, ruffle {ECO:0000250}. Note=Shuttles between cytoplasm and nucleus. Colocalizes with the actin cytoskeleton and actin-rich membrane ruffles (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Detected in peripheral blood B-cells (at protein level). Detected in spleen, liver and peripheral blood. {ECO:0000269PubMed:11594764, ECO:0000269PubMed:15381729}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.

Experimentally validated
Total	16 [view]
Protein-Protein	16 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001784	phosphotyrosine binding
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0002820	negative regulation of adaptive immune response
GO:0050732	negative regulation of peptidyl-tyrosine phosphorylation
GO:0050869	negative regulation of B cell activation

Cellular Component

GO:0001726	ruffle
GO:0005634	nucleus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR001452 SH3 domain
IPR001660 Sterile alpha motif domain
IPR011510 Sterile alpha motif, type 2
IPR011511 Variant SH3 domain
IPR013761 Sterile alpha motif/pointed domain
IPR021090 SAM/SH3 domain-containing
IPR021129 Sterile alpha motif, type 1

PFAM

PF00018
PF14604
PF07647
PF07653
PF12485
PF00536

PRINTS

PR00452

PIRSF

SMART

SM00326
SM00454

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt