InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MICAL3

Summary

InnateDB Protein

IDBP-227935.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MICAL3

Protein Name

microtubule associated monoxygenase, calponin and LIM domain containing 3

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000383406

InnateDB Gene

IDBG-401904 (MICAL3)

Protein Structure

UniProt Annotation

Function

Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin. Acts by modifying actin subunits through the addition of oxygen to form methionine-sulfoxide, leading to promote actin filament severing and prevent repolymerization. Involved in exocytic vesicles tethering and fusion: the monooxygenase activity is required for this process. {ECO:0000269PubMed:21596566, ECO:0000269PubMed:24440334}.

Subcellular Localization

Cytoplasm. Cytoplasm, cytoskeleton. Nucleus. Note=Mainly localizes in the nucleus. {ECO:0000269PubMed:24440334}.

Disease Associations

Tissue Specificity

Ubiquitous. {ECO:0000269PubMed:15694364}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016709	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
GO:0071949	FAD binding

Biological Process

GO:0006887	exocytosis
GO:0007010	cytoskeleton organization
GO:0030042	actin filament depolymerization
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005856	cytoskeleton

Protein Structure and Domains

PDB ID

InterPro

IPR001715 Calponin homology domain
IPR001781 Zinc finger, LIM-type
IPR002938 Monooxygenase, FAD-binding
IPR003042 Aromatic-ring hydroxylase-like
IPR022613 Calmodulin-regulated spectrin-associated protein, CH domain

PFAM

PF00307
PF00412
PF01494
PF11971

PRINTS

PR00420

PIRSF

SMART

SM00033
SM00132

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt