Version 5.4
Homo sapiens Protein: JAM2
Summary
InnateDB Protein IDBP-227998.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol JAM2
Protein Name junctional adhesion molecule 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000383376
InnateDB Gene IDBG-1072 (JAM2)
Protein Structure
UniProt Annotation
Function May play a role in the processes of lymphocyte homing to secondary lymphoid organs.
Subcellular Localization Cell junction, tight junction {ECO:0000250}. Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=Localized at tight junctions of both epithelial and endothelial cells. {ECO:0000250}.
Disease Associations
Tissue Specificity Highest expression in the heart, placenta, lung, foreskin and lymph node. Prominently expressed on high endothelial venules, also present on the endothelia of other vessels. Localized to the intercellular boundaries of high endothelial cells. {ECO:0000269PubMed:10779521}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
Experimentally validated
Total 11 [view]
Protein-Protein 11 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0007162 negative regulation of cell adhesion
GO:0007596 blood coagulation
GO:0016337 single organismal cell-cell adhesion
GO:0030198 extracellular matrix organization
GO:0050900 leukocyte migration
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005923 tight junction
Protein Structure and Domains
PDB ID
InterPro IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR013098 Immunoglobulin I-set
IPR013106 Immunoglobulin V-set domain
IPR013151 Immunoglobulin
PFAM PF07679
PF07686
PF00047
PRINTS
PIRSF
SMART SM00408
SM00409
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P57087
PhosphoSite PhosphoSite-P57087
TrEMBL
UniProt Splice Variant
Entrez Gene 58494
UniGene Hs.657654
RefSeq NP_001257337
HUGO HGNC:14686
OMIM 606870
CCDS CCDS58787
HPRD 06041
IMGT
EMBL AF255910 AK294769 AK312708 AP000223 AP000224 AP000225 AP000226 AY016009 AY077698 AY358361 BC017779
GenPept AAF81223 AAG49022 AAH17779 AAL82538 AAQ88727 BAG35586 BAG57900

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca