InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NEK10

Summary

InnateDB Protein

IDBP-22803.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NEK10

Protein Name

NIMA (never in mitosis gene a)- related kinase 10

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000343847

InnateDB Gene

IDBG-22793 (NEK10)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005488	binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0046872	metal ion binding

Biological Process

GO:0006468	protein phosphorylation
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0031954	positive regulation of protein autophosphorylation
GO:0043406	positive regulation of MAP kinase activity
GO:0070372	regulation of ERK1 and ERK2 cascade
GO:1902749	regulation of cell cycle G2/M phase transition

Cellular Component

GO:1902911

protein kinase complex

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR002575 Aminoglycoside phosphotransferase
IPR011009 Protein kinase-like domain
IPR016024 Armadillo-type fold
IPR018934 RIO-like kinase
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714
PF01636
PF01163

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt