InnateDB Protein
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IDBP-22809.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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MOB1B
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Protein Name
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MOB kinase activator 1B
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000310189
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InnateDB Gene
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IDBG-22807 (MOB1B)
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Protein Structure
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Function |
Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38L. {ECO:0000269PubMed:15067004, ECO:0000269PubMed:19739119}.
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Subcellular Localization |
Cytoplasm {ECO:0000269PubMed:15067004}. Nucleus {ECO:0000269PubMed:15067004}.
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Disease Associations |
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Tissue Specificity |
Adrenal gland, bone marrow, brain, lung, placenta, prostate, salivary gland, skeletal muscle, testis, thymus, thyroid gland, uterus, colon with mucosa, fetal brain and fetal liver. {ECO:0000269PubMed:19739119}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 47 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
47
[view]
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Protein-Protein |
47
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR005301
Mob1/phocein
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PFAM |
PF03637
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q7L9L4
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PhosphoSite |
PhosphoSite-Q7L9L4
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TrEMBL |
Q4W5E0
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UniProt Splice Variant |
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Entrez Gene |
92597
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UniGene |
Hs.741364
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RefSeq |
NP_775739
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HUGO |
HGNC:29801
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OMIM |
609282
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CCDS |
CCDS34002
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HPRD |
17582
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IMGT |
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EMBL |
AC021989
AC093851
AC108014
AJ577473
AK299481
AK313513
BC038112
CH471057
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GenPept |
AAH38112
AAY41047
BAG36293
BAG61445
CAE12091
EAX05636
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