InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NBEA

Summary

InnateDB Protein

IDBP-228151.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NBEA

Protein Name

neurobeachin

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000383295

InnateDB Gene

IDBG-23565 (NBEA)

Protein Structure

UniProt Annotation

Function

Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the membrane. May anchor the kinase to cytoskeletal and/or organelle-associated proteins (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Predominant in many brain structures. Also expressed at medium levels in spleen, thymus, prostate, testis and ovary. Low level expression is seen in heart, kidney, pancreas, skeletal muscle and intestine. {ECO:0000269PubMed:12160729}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005488	binding
GO:0005515	protein binding
GO:0019901	protein kinase binding

Biological Process

GO:0008104

protein localization

Cellular Component

GO:0005802	trans-Golgi network
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0012505	endomembrane system

Protein Structure and Domains

PDB ID

InterPro

IPR000409 BEACH domain
IPR001680 WD40 repeat
IPR008985 Concanavalin A-like lectin/glucanases superfamily
IPR010508 Domain of unknown function DUF1088
IPR016024 Armadillo-type fold
IPR017986 WD40-repeat-containing domain

PFAM

PF02138
PF00400
PF06469

PRINTS

PIRSF

SMART

SM01026
SM00320

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8NFP9