Version 5.4
Homo sapiens Protein: SIAH3
Summary
InnateDB Protein IDBP-228326.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SIAH3
Protein Name seven in absentia homolog 3 (Drosophila)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000383256
InnateDB Gene IDBG-228324 (SIAH3)
Protein Structure
UniProt Annotation
Function Negative regulator of PARK2 translocation to damaged mitochondria. Acts probably by destabilizing PINK1 protein, hence inhibiting PARK2 targeting to dysfunctional depolarized mitochondria. {ECO:0000269PubMed:24270810}.
Subcellular Localization Mitochondrion {ECO:0000269PubMed:24270810}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0046872 metal ion binding
Biological Process
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0007275 multicellular organismal development
Cellular Component
GO:0005634 nucleus
GO:0005739 mitochondrion
Protein Structure and Domains
PDB ID
InterPro IPR008974 TRAF-like
IPR018121 Seven-in-absentia protein, TRAF-like domain
PFAM PF03145
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8IW03
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 283514
UniGene Hs.710931
RefSeq NP_942146
HUGO HGNC:30553
OMIM 615609
CCDS CCDS41883
HPRD 14145
IMGT
EMBL AK096522 AL157819 BC041372
GenPept AAH41372 BAC04809 CAX15065

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

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Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca