InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SKOR2

Summary

InnateDB Protein

IDBP-228329.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SKOR2

Protein Name

SKI family transcriptional corepressor 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000383255

InnateDB Gene

IDBG-228327 (SKOR2)

Protein Structure

UniProt Annotation

Function

Exhibits transcriptional repressor activity (By similarity). Acts as a TGF-beta antagonist in the nervous system. {ECO:0000250, ECO:0000269PubMed:16200078}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:16200078}. Cytoplasm {ECO:0000269PubMed:16200078}.

Disease Associations

Tissue Specificity

Expressed in cerebellum, spinal cord and testis. Isoform 2 is present in cerebellum (at protein level). {ECO:0000269PubMed:16200078}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003714	transcription corepressor activity
GO:0046332	SMAD binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway