Version 5.4
Homo sapiens Protein: ICOSLG
Summary
InnateDB Protein IDBP-228400.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ICOSLG
Protein Name inducible T-cell co-stimulator ligand
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000383228
InnateDB Gene IDBG-5107 (ICOSLG)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0005515 protein binding
Biological Process
GO:0006952 defense response
GO:0006972 hyperosmotic response
GO:0007165 signal transduction
GO:0031295 T cell costimulation
GO:0042104 positive regulation of activated T cell proliferation
GO:0042110 T cell activation
GO:0042113 B cell activation
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR007110 Immunoglobulin-like domain
IPR013162 CD80-like, immunoglobulin C2-set
PFAM PF08205
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O75144
PhosphoSite PhosphoSite-O75144
TrEMBL
UniProt Splice Variant
Entrez Gene 23308
UniGene Hs.14155
RefSeq NP_001269980
HUGO HGNC:17087
OMIM 605717
CCDS CCDS63377
HPRD 05757
IMGT
EMBL AB014553 AF199028 AF216749 AF289028 AK090492 AP001058 AP001059 AX100595 BC064637 CH471079
GenPept AAF34739 AAG01176 AAH64637 AAK16241 BAA31628 BAG52170 CAC36465 EAX09446

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca