InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GABRB3

Summary

InnateDB Protein

IDBP-228838.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GABRB3

Protein Name

gamma-aminobutyric acid (GABA) A receptor, beta 3

Synonyms

ECA5;

Species

Homo sapiens

Ensembl Protein

ENSP00000383049

InnateDB Gene

IDBG-4360 (GABRB3)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004890	GABA-A receptor activity
GO:0005230	extracellular ligand-gated ion channel activity
GO:0005254	chloride channel activity
GO:0022851	GABA-gated chloride ion channel activity

Biological Process

GO:0006810	transport
GO:0006811	ion transport
GO:0007165	signal transduction
GO:0007268	synaptic transmission
GO:0034220	ion transmembrane transport
GO:0055085	transmembrane transport
GO:0060021	palate development
GO:0071420	cellular response to histamine
GO:1902476	chloride transmembrane transport

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030054	cell junction
GO:0034707	chloride channel complex
GO:0045211	postsynaptic membrane
GO:1902711	GABA-A receptor complex

Protein Structure and Domains

PDB ID

InterPro

IPR002289 Gamma-aminobutyric-acid A receptor, beta subunit
IPR006028 Gamma-aminobutyric acid A receptor/Glycine receptor alpha
IPR006029 Neurotransmitter-gated ion-channel transmembrane domain
IPR006201 Neurotransmitter-gated ion-channel
IPR006202 Neurotransmitter-gated ion-channel ligand-binding

PFAM

PF02932
PF02931

PRINTS

PR01160
PR00253
PR00252

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P28472