Homo sapiens Protein: SULT1A2
Summary
InnateDB Protein IDBP-22936.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SULT1A2
Protein Name sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
Synonyms HAST4; P-PST; ST1A2; STP2; TSPST2;
Species Homo sapiens
Ensembl Protein ENSP00000338742
InnateDB Gene IDBG-22934 (SULT1A2)
Protein Structure
UniProt Annotation
Function Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of catecholamines, phenolic drugs and neurotransmitters. Is also responsible for the sulfonation and activation of minoxidil. Mediates the metabolic activation of carcinogenic N-hydroxyarylamines to DNA binding products and could so participate as modulating factor of cancer risk.
Subcellular Localization Cytoplasm.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004062 aryl sulfotransferase activity
GO:0008146 sulfotransferase activity
GO:0047894 flavonol 3-sulfotransferase activity
Biological Process
GO:0006584 catecholamine metabolic process
GO:0006805 xenobiotic metabolic process
GO:0008152 metabolic process
GO:0008202 steroid metabolic process
GO:0009309 amine biosynthetic process
GO:0018958 phenol-containing compound metabolic process
GO:0044281 small molecule metabolic process
GO:0050427 3'-phosphoadenosine 5'-phosphosulfate metabolic process
GO:0051923 sulfation
Cellular Component
GO:0005829 cytosol
Protein Structure and Domains
PDB ID
InterPro IPR000863 Sulfotransferase domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase
PFAM PF00685
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P50226
PhosphoSite PhosphoSite-P50226
TrEMBL E9PKR8
UniProt Splice Variant
Entrez Gene 6799
UniGene Hs.546304
RefSeq NP_001045
HUGO HGNC:11454
OMIM 601292
CCDS CCDS10636
HPRD 03187
IMGT
EMBL AC020765 BC113727 BC113729 U28169 U28170 U33886 U34804 U72196 U72197 U72198 U72199 U72200 U72201 U72202 U76619 X78282
GenPept AAB08970 AAB09658 AAB09659 AAB09758 AAB18753 AAC51149 AAI13728 AAI13730 ABX65442 CAA55088