InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: KCNU1

Summary

InnateDB Protein

IDBP-229532.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KCNU1

Protein Name

potassium channel, subfamily U, member 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000382770

InnateDB Gene

IDBG-229530 (KCNU1)

Protein Structure

UniProt Annotation

Function

Testis-specific potassium channel activated by both intracellular pH and membrane voltage that mediates export of K(+). May represent the primary spermatozoan K(+) current. In contrast to KCNMA1/SLO1, it is not activated by Ca(2+) or Mg(2+). Critical for fertility. May play an important role in sperm osmoregulation required for the acquisition of normal morphology and motility when faced with osmotic challenges, such as those experienced after mixing with seminal fluid and entry into the vagina. {ECO:0000269PubMed:23129643}.

Subcellular Localization

Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Testis-specific. {ECO:0000269PubMed:9452476}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005249	voltage-gated potassium channel activity
GO:0005267	potassium channel activity
GO:0015269	calcium-activated potassium channel activity
GO:0060072	large conductance calcium-activated potassium channel activity

Biological Process

GO:0006813	potassium ion transport
GO:0007338	single fertilization
GO:0032504	multicellular organism reproduction
GO:0034765	regulation of ion transmembrane transport
GO:0035036	sperm-egg recognition
GO:0071805	potassium ion transmembrane transport