InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: KDM5A

Summary

InnateDB Protein

IDBP-229708.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KDM5A

Protein Name

lysine (K)-specific demethylase 5A

Synonyms

RBBP-2; RBBP2; RBP2;

Species

Homo sapiens

Ensembl Protein

ENSP00000382688

InnateDB Gene

IDBG-11318 (KDM5A)

Protein Structure

UniProt Annotation

Function

Histone demethylase that specifically demethylates 'Lys- 4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. May stimulate transcription mediated by nuclear receptors. May be involved in transcriptional regulation of Hox proteins during cell differentiation. May participate in transcriptional repression of cytokines such as CXCL12. {ECO:0000269PubMed:11358960, ECO:0000269PubMed:15949438, ECO:0000269PubMed:17320160, ECO:0000269PubMed:17320161, ECO:0000269PubMed:17320163}.

Subcellular Localization

Nucleus, nucleolus {ECO:0000269PubMed:15949438, ECO:0000269PubMed:7935440}. Note=Occupies promoters of genes involved in RNA metabolism and mitochondrial function. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 35 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	35 [view]
Protein-Protein	28 [view]
Protein-DNA	6 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016706	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors

Biological Process

GO:0006366	transcription from RNA polymerase II promoter
GO:0007275	multicellular organismal development
GO:0016568	chromatin modification
GO:0045893	positive regulation of transcription, DNA-templated
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0019907	cyclin-dependent protein kinase activating kinase holoenzyme complex

Protein Structure and Domains

PDB ID

InterPro

IPR001606 ARID/BRIGHT DNA-binding domain
IPR001965 Zinc finger, PHD-type
IPR003347 JmjC domain
IPR003349 Transcription factor jumonji, JmjN
IPR004198 Zinc finger, C5HC2-type
IPR011011 Zinc finger, FYVE/PHD-type
IPR013637 Lysine-specific demethylase-like domain
IPR019787 Zinc finger, PHD-finger

PFAM