InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CACNA1C

Summary

InnateDB Protein

IDBP-229929.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CACNA1C

Protein Name

calcium channel, voltage-dependent, L type, alpha 1C subunit

Synonyms

CACH2; CACN2; CACNL1A1; CaV1.2; CCHL1A1; LQT8; TS;

Species

Homo sapiens

Ensembl Protein

ENSP00000382512

InnateDB Gene

IDBG-12068 (CACNA1C)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	24 [view]
Protein-Protein	24 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005216	ion channel activity
GO:0005245	voltage-gated calcium channel activity
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0008331	high voltage-gated calcium channel activity
GO:0046872	metal ion binding
GO:0051393	alpha-actinin binding

Biological Process

GO:0006112	energy reserve metabolic process
GO:0006811	ion transport
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0007411	axon guidance
GO:0010881	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
GO:0034765	regulation of ion transmembrane transport
GO:0035585	calcium-mediated signaling using extracellular calcium source
GO:0044281	small molecule metabolic process
GO:0050796	regulation of insulin secretion
GO:0055085	transmembrane transport
GO:0060402	calcium ion transport into cytosol
GO:0070509	calcium ion import
GO:0086010	membrane depolarization during action potential
GO:0086064	cell communication by electrical coupling involved in cardiac conduction

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005891	voltage-gated calcium channel complex
GO:0014069	postsynaptic density
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030018	Z disc

Protein Structure and Domains

PDB ID

InterPro

IPR002077 Voltage-dependent calcium channel, alpha-1 subunit
IPR005446 Voltage-dependent calcium channel, L-type, alpha-1 subunit
IPR005451 Voltage-dependent calcium channel, L-type, alpha-1C subunit
IPR005821 Ion transport domain
IPR013122 Polycystin cation channel, PKD1/PKD2
IPR014873 Voltage-dependent calcium channel, alpha-1 subunit, IQ domain

PFAM

PF00520
PF08016
PF08763

PRINTS

PR00167
PR01630
PR01635

PIRSF

SMART

SM01062

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt