Version 5.4
| Homo sapiens Protein: PCDH11Y | |||||||
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| Summary | |||||||
| InnateDB Protein | IDBP-23.7 | ||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||
| Gene Symbol | PCDH11Y | ||||||
| Protein Name | protocadherin 11 Y-linked | ||||||
| Synonyms | |||||||
| Species | Homo sapiens | ||||||
| Ensembl Protein | ENSP00000330552 | ||||||
| InnateDB Gene | IDBG-21 (PCDH11Y) | ||||||
| Protein Structure |
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| UniProt Annotation | |||||||
| Function | Potential calcium-dependent cell-adhesion protein. | ||||||
| Subcellular Localization | Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. | ||||||
| Disease Associations | Note=A chromosomal aberration involving PCDH11Y is a cause of multiple congenital abnormalities, including severe bilateral vesicoureteral reflux (VUR) with ureterovesical junction defects. Translocation t(Y;3)(p11;p12) with ROBO2. | ||||||
| Tissue Specificity | Expressed strongly in fetal brain and brain (cortex, amygdala, thalamus, substantia nigra, hippocampus, caudate nucleus and corpus callosum). Expressed at low level in testis. Expressed in apoptosis-resistant cells. {ECO:0000269PubMed:11003707, ECO:0000269PubMed:12420223, ECO:0000269PubMed:14727141, ECO:0000269PubMed:16331680}. | ||||||
| Comments | |||||||
| Interactions | |||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||
| PDB ID | |||||||
| InterPro |
IPR002126
Cadherin IPR013164 Cadherin, N-terminal IPR013585 Protocadherin IPR015919 Cadherin-like |
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| PFAM |
PF00028
PF08266 PF08374 |
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| PRINTS |
PR00205
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| PIRSF | |||||||
| SMART |
SM00112
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| TIGRFAMs | |||||||
| Post-translational Modifications | |||||||
| Modification | |||||||
| Cross-References | |||||||
| SwissProt | Q9BZA8 | ||||||
| PhosphoSite | PhosphoSite-Q9BZA8 | ||||||
| TrEMBL | |||||||
| UniProt Splice Variant | |||||||
| Entrez Gene | 83259 | ||||||
| UniGene | Hs.661308 | ||||||
| RefSeq | NP_116753 | ||||||
| HUGO | HGNC:15813 | ||||||
| OMIM | 400022 | ||||||
| CCDS | CCDS14776 | ||||||
| HPRD | 11847 | ||||||
| IMGT | |||||||
| EMBL | AF277053 AF332216 AF332217 AJ276803 AJ564958 AJ564959 AJ564960 AJ564961 AJ564962 AJ564963 AJ564966 AJ564969 | ||||||
| GenPept | AAK13468 AAK13469 AAL55729 CAC13122 CAD92429 CAD92430 CAD92431 CAD92432 CAD92433 CAD92434 CAD92437 CAD92440 | ||||||