Version 5.4
Homo sapiens Protein: KRTAP5-3
Summary
InnateDB Protein IDBP-230085.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KRTAP5-3
Protein Name keratin associated protein 5-3
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000382592
InnateDB Gene IDBG-19515 (KRTAP5-3)
Protein Structure
UniProt Annotation
Function In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high- sulfur and high-glycine-tyrosine keratins.
Subcellular Localization
Disease Associations
Tissue Specificity Restricted to hair root, not detected in any other tissues. {ECO:0000269PubMed:15144888}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
GO:0009055 electron carrier activity
GO:0046872 metal ion binding
GO:0051536 iron-sulfur cluster binding
Biological Process
Cellular Component
GO:0045095 keratin filament
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6L8H2
PhosphoSite PhosphoSite-Q6L8H2
TrEMBL
UniProt Splice Variant
Entrez Gene 387266
UniGene
RefSeq NP_001012726
HUGO HGNC:23598
OMIM
CCDS CCDS41591
HPRD 12395
IMGT
EMBL AB126072 AJ628246 AY597812
GenPept AAT09005 BAD20199 CAF31638

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

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Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca