Version 5.4
Homo sapiens Protein: BCL6B
Summary
InnateDB Protein IDBP-23015.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BCL6B
Protein Name B-cell CLL/lymphoma 6, member B
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000293805
InnateDB Gene IDBG-23013 (BCL6B)
Protein Structure
UniProt Annotation
Function Acts as a sequence-specific transcriptional repressor in association with BCL6. May function in a narrow stage or be related to some events in the early B-cell development. {ECO:0000269PubMed:11855826}.
Subcellular Localization Nucleus {ECO:0000250}.
Disease Associations
Tissue Specificity Ubiquitously expressed with higher expression found in heart and placenta. {ECO:0000269PubMed:11855826}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 5 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0046872 metal ion binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro IPR000210 BTB/POZ-like
IPR007087 Zinc finger, C2H2
IPR011333 BTB/POZ fold
IPR013069 BTB/POZ
IPR015880 Zinc finger, C2H2-like
PFAM PF00096
PF00651
PRINTS
PIRSF
SMART SM00225
SM00355
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8N143
PhosphoSite PhosphoSite-Q8N143
TrEMBL Q15934
UniProt Splice Variant
Entrez Gene 255877
UniGene
RefSeq NP_862827
HUGO HGNC:1002
OMIM 608992
CCDS CCDS42248
HPRD 16414
IMGT
EMBL AB076580 AB076581 AC040977 AK122893 AK292878 AK293102 BC059404 CH471108 M88371
GenPept AAA61329 AAH59404 BAC00962 BAC00963 BAF85567 BAF85791 BAG53785 EAW90273 EAW90274

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca