InnateDB Protein
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IDBP-230154.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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PAN3
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Protein Name
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PAN3 poly(A) specific ribonuclease subunit homolog (S. cerevisiae)
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000382522
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InnateDB Gene
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IDBG-19995 (PAN3)
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Protein Structure
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Function |
Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA when the poly(A) stretch is bound by poly(A)-binding protein (PABP), which is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. PAN3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with PABP and to miRNA targets via its interaction with GW182 family proteins. {ECO:0000255HAMAP-Rule:MF_03181, ECO:0000269PubMed:14583602, ECO:0000269PubMed:23932717}.
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Subcellular Localization |
Cytoplasm, P-body {ECO:0000255HAMAP- Rule:MF_03181, ECO:0000269PubMed:14583602, ECO:0000269PubMed:18625844}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
8
[view]
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Protein-Protein |
8
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000719
Protein kinase domain
IPR011009
Protein kinase-like domain
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PFAM |
PF00069
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q58A45
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PhosphoSite |
PhosphoSite-Q58A45
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TrEMBL |
Q6ZMN5
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UniProt Splice Variant |
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Entrez Gene |
255967
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UniGene |
Hs.701302
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RefSeq |
XP_005266389
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HUGO |
HGNC:29991
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OMIM |
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CCDS |
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HPRD |
17818
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IMGT |
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EMBL |
AB107584
AB109552
AK091307
AK131556
AK296435
AL138712
AL356915
BC024318
BC128179
BC128180
BX647740
EF088216
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GenPept |
AAH24318
AAI28180
AAI28181
ABK41888
BAC03632
BAD02262
BAD18690
BAD93184
BAH12353
CAI12449
CAI12450
CAI14848
CAI45987
CAM20921
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