InnateDB Protein
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IDBP-2302.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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ASXL3
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Protein Name
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additional sex combs like 3 (Drosophila)
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000269197
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InnateDB Gene
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IDBG-2300 (ASXL3)
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Protein Structure
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Function |
Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via methylation of histones, rendering chromatin heritably changed in its expressibility (By similarity). {ECO:0000250}.
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Subcellular Localization |
Nucleus {ECO:0000305}.
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Disease Associations |
Bainbridge-Ropers syndrome (BRPS) [MIM:615485]: A syndrome characterized by psychomotor retardation, feeding problems, severe postnatal growth retardation in some patients, arched eyebrows, anteverted nares, and ulnar deviation of the hands. {ECO:0000269PubMed:23383720}. Note=The disease is caused by mutations affecting the gene represented in this entry.
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Tissue Specificity |
Expressed in pancreatic islets, testis, neuroblastoma, head and neck tumor. {ECO:0000269PubMed:15138607}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR011011
Zinc finger, FYVE/PHD-type
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9C0F0
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PhosphoSite |
PhosphoSite-Q9C0F0
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TrEMBL |
K7EQY1
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UniProt Splice Variant |
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Entrez Gene |
80816
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UniGene |
Hs.608090
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RefSeq |
NP_085135
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HUGO |
HGNC:29357
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OMIM |
615115
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CCDS |
CCDS45847
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HPRD |
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IMGT |
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EMBL |
AB051500
AC010798
AC023192
AC090989
AK056450
AK131454
AL133050
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GenPept |
BAB21804
BAB71186
BAD18599
CAB61377
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