InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: JAG2

Summary

InnateDB Protein

IDBP-23021.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

JAG2

Protein Name

jagged 2

Synonyms

HJ2; SER2;

Species

Homo sapiens

Ensembl Protein

ENSP00000328169

InnateDB Gene

IDBG-23019 (JAG2)

Protein Structure

UniProt Annotation

Function

Putative Notch ligand involved in the mediation of Notch signaling. Involved in limb development (By similarity). {ECO:0000250}.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Expressed in heart, placenta and skeletal muscle and to a lesser extend in pancreas. Very low expression in brain, lung, liver and kidney.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005112	Notch binding
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0008083	growth factor activity

Biological Process

GO:0001501	skeletal system development
GO:0001701	in utero embryonic development
GO:0003016	respiratory system process
GO:0007049	cell cycle
GO:0007154	cell communication
GO:0007219	Notch signaling pathway
GO:0007220	Notch receptor processing
GO:0007275	multicellular organismal development
GO:0007283	spermatogenesis
GO:0009912	auditory receptor cell fate commitment
GO:0016331	morphogenesis of embryonic epithelium
GO:0030154	cell differentiation
GO:0030155	regulation of cell adhesion
GO:0030217	T cell differentiation
GO:0030334	regulation of cell migration
GO:0042127	regulation of cell proliferation
GO:0042475	odontogenesis of dentin-containing tooth
GO:0042492	gamma-delta T cell differentiation
GO:0045061	thymic T cell selection
GO:1990134	epithelial cell apoptotic process involved in palatal shelf morphogenesis

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000742 Epidermal growth factor-like domain
IPR001007 von Willebrand factor, type C
IPR001774 Delta/Serrate/lag-2 (DSL) protein
IPR001881 EGF-like calcium-binding domain
IPR006552 VWC out
IPR011651 Notch ligand, N-terminal
IPR013111 EGF-like domain, extracellular

PFAM

PF00008
PF00093
PF01414
PF07645
PF07657
PF07974

PRINTS

PIRSF

SMART

SM00181
SM00214
SM00051
SM00179
SM00215

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9Y219