InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: LAMA3

Summary

InnateDB Protein

IDBP-230216.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LAMA3

Protein Name

laminin, alpha 3

Synonyms

BM600; E170; lama3a; LAMNA; LOCS;

Species

Homo sapiens

Ensembl Protein

ENSP00000382432

InnateDB Gene

IDBG-1631 (LAMA3)

Protein Structure

UniProt Annotation

Function

Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.Laminin-5 is thought to be involved in (1) cell adhesion via integrin alpha-3/beta-1 in focal adhesion and integrin alpha- 6/beta-4 in hemidesmosomes, (2) signal transduction via tyrosine phosphorylation of pp125-FAK and p80, (3) differentiation of keratinocytes.

Subcellular Localization

Secreted, extracellular space, extracellular matrix, basement membrane. Note=Major component.

Disease Associations

Epidermolysis bullosa, junctional, Herlitz type (H-JEB) [MIM:226700]: An infantile and lethal form of junctional epidermolysis bullosa, a group of blistering skin diseases characterized by tissue separation which occurs within the dermo- epidermal basement In the Herlitz type, death occurs usually within the first six months of life. Occasionally, children survive to teens. It is marked by bullous lesions at birth and extensive denudation of skin and mucous membranes that may be hemorrhagic. Note=The disease is caused by mutations affecting the gene represented in this entry.Laryngoonychocutaneous syndrome (LOCS) [MIM:245660]: Autosomal recessive epithelial disorder confined to the Punjabi Muslim population. The condition is characterized by cutaneous erosions, nail dystrophy and exuberant vascular granulation tissue in certain epithelia, especially conjunctiva and larynx. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Skin; respiratory, urinary, and digestive epithelia and in other specialized tissues with prominent secretory or protective functions. Epithelial basement membrane, and epithelial cell tongue that migrates into a wound bed. A differential and focal expression of the subunit alpha-3 is observed in the CNS.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.

Experimentally validated
Total	6 [view]
Protein-Protein	5 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0004871	signal transducer activity
GO:0005102	receptor binding
GO:0005198	structural molecule activity
GO:0005515	protein binding

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0007155	cell adhesion
GO:0007165	signal transduction
GO:0008544	epidermis development
GO:0022617	extracellular matrix disassembly
GO:0030155	regulation of cell adhesion
GO:0030198	extracellular matrix organization
GO:0030334	regulation of cell migration
GO:0031581	hemidesmosome assembly
GO:0034329	cell junction assembly
GO:0045995	regulation of embryonic development

Cellular Component

GO:0005576	extracellular region
GO:0005604	basement membrane
GO:0005606	laminin-1 complex

Protein Structure and Domains

PDB ID

InterPro

IPR000034 Laminin B type IV
IPR000742 Epidermal growth factor-like domain
IPR001791 Laminin G domain
IPR002049 EGF-like, laminin
IPR008211 Laminin, N-terminal
IPR008979 Galactose-binding domain-like
IPR008985 Concanavalin A-like lectin/glucanases superfamily
IPR009030 Insulin-like growth factor binding protein, N-terminal
IPR009254 Laminin I
IPR010307 Laminin domain II
IPR015988 STAT transcription factor, coiled coil
IPR018031 Laminin B, subgroup

PFAM