Version 5.4
Homo sapiens Protein: UBXN2B
Summary
InnateDB Protein IDBP-230253.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol UBXN2B
Protein Name UBX domain protein 2B
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000382507
InnateDB Gene IDBG-230251 (UBXN2B)
Protein Structure
UniProt Annotation
Function Adapter protein required for Golgi and endoplasmic reticulum biogenesis. Involved in Golgi and endoplasmic reticulum maintenance during interphase and in their reassembly at the end of mitosis. The complex formed with VCP has membrane fusion activity; membrane fusion activity requires USO1-GOLGA2 tethering and BET1L. VCPIP1 is also required, but not its deubiquitinating activity. {ECO:0000269PubMed:17141156}.
Subcellular Localization Nucleus {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}. Golgi apparatus {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
Cellular Component
GO:0005634 nucleus
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005829 cytosol
Protein Structure and Domains
PDB ID
InterPro IPR001012 UBX domain
IPR012989 SEP domain
IPR029071 Ubiquitin-related domain
PFAM PF00789
PF08059
PRINTS
PIRSF
SMART SM00166
SM00553
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q14CS0
PhosphoSite PhosphoSite-Q14CS0
TrEMBL
UniProt Splice Variant
Entrez Gene 137886
UniGene Hs.668402
RefSeq NP_001071087
HUGO HGNC:27035
OMIM 610686
CCDS CCDS43741
HPRD
IMGT
EMBL AK126300 BC113645
GenPept AAI13646 BAG54305

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca