Version 5.4
Homo sapiens Protein: PROL1
Summary
InnateDB Protein IDBP-230312.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PROL1
Protein Name proline rich, lacrimal 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000382485
InnateDB Gene IDBG-22483 (PROL1)
Protein Structure
UniProt Annotation
Function Opiorphin is an endogenous inhibitor of neprilysin and aminopeptidase N. Inhibits the breakdown of substance P, Mca-BK2 and Met-enkephalin by neprilysin in vitro with IC(50) values of 29 uM, 33 uM and 33 uM respectively. Inhibits the breakdown of Ala- pNA by aminopeptidase N in vitro with an IC(50) of 65 uM. Has a potent analgesic effect when administered to rats by intravenous injection. {ECO:0000269PubMed:17101991}.
Subcellular Localization Secreted {ECO:0000269PubMed:17101991}.
Disease Associations
Tissue Specificity Abundantly expressed in lacrimal gland where it found in the secretory endpieces. Also expressed at modest levels in the submandibular gland.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004866 endopeptidase inhibitor activity
GO:0030414 peptidase inhibitor activity
Biological Process
GO:0001895 retina homeostasis
GO:0010951 negative regulation of endopeptidase activity
GO:0051930 regulation of sensory perception of pain
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q99935
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 58503
UniGene Hs.661425
RefSeq NP_067048
HUGO HGNC:17279
OMIM 608936
CCDS CCDS43235
HPRD 16408
IMGT
EMBL AC106884 CH471057 S83198
GenPept AAB46823 EAX05620

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

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Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca