InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MAP3K1

Summary

InnateDB Protein

IDBP-230467.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MAP3K1

Protein Name

mitogen-activated protein kinase kinase kinase 1

Synonyms

MAPKKK1; MEKK; MEKK 1; MEKK1; SRXY6;

Species

Homo sapiens

Ensembl Protein

ENSP00000382423

InnateDB Gene

IDBG-22000 (MAP3K1)

Protein Structure

UniProt Annotation

Function

Component of a protein kinase signal transduction cascade. Activates the ERK and JNK kinase pathways by phosphorylation of MAP2K1 and MAP2K4. Activates CHUK and IKBKB, the central protein kinases of the NF-kappa-B pathway. {ECO:0000269PubMed:9808624}.

Subcellular Localization

Disease Associations

46,XY sex reversal 6 (SRXY6) [MIM:613762]: A disorder of sex development. Affected individuals have a 46,XY karyotype but present as phenotypically normal females. {ECO:0000269PubMed:21129722}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 108 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.

Experimentally validated
Total	108 [view]
Protein-Protein	105 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	23 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004709	MAP kinase kinase kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005488	binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008270	zinc ion binding
GO:0008545	JUN kinase kinase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0019901	protein kinase binding

Biological Process

GO:0000186	activation of MAPKK activity
GO:0002224	toll-like receptor signaling pathway
GO:0002755	MyD88-dependent toll-like receptor signaling pathway
GO:0003382	epithelial cell morphogenesis
GO:0006468	protein phosphorylation
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0007254	JNK cascade
GO:0007257	activation of JUN kinase activity
GO:0008637	apoptotic mitochondrial changes
GO:0030334	regulation of cell migration
GO:0030838	positive regulation of actin filament polymerization
GO:0034134	toll-like receptor 2 signaling pathway
GO:0034142	toll-like receptor 4 signaling pathway
GO:0034146	toll-like receptor 5 signaling pathway
GO:0034162	toll-like receptor 9 signaling pathway
GO:0034166	toll-like receptor 10 signaling pathway
GO:0038095	Fc-epsilon receptor signaling pathway
GO:0038123	toll-like receptor TLR1:TLR2 signaling pathway
GO:0038124	toll-like receptor TLR6:TLR2 signaling pathway
GO:0042060	wound healing
GO:0043010	camera-type eye development
GO:0045087	innate immune response (InnateDB)
GO:0061029	eyelid development in camera-type eye
GO:0071260	cellular response to mechanical stimulus

Cellular Component

GO:0005829

cytosol

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR001841 Zinc finger, RING-type
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR007527 Zinc finger, SWIM-type
IPR011009 Protein kinase-like domain
IPR016024 Armadillo-type fold
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714
PF13639
PF14634
PF04434

PRINTS

PR00109

PIRSF

SMART

SM00184
SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt