InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PTPN6

Summary

InnateDB Protein

IDBP-230608.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PTPN6

Protein Name

protein tyrosine phosphatase, non-receptor type 6

Synonyms

HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1; SHP-1L; SHP1;

Species

Homo sapiens

Ensembl Protein

ENSP00000382376

InnateDB Gene

IDBG-15719 (PTPN6)

Protein Structure

UniProt Annotation

Function

Modulates signaling by tyrosine phosphorylated cell surface receptors such as KIT and the EGF receptor/EGFR. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation. Plays a key role in hematopoiesis. {ECO:0000269PubMed:11266449}.

Subcellular Localization

Cytoplasm. Nucleus. Note=In neurons, translocates into the nucleus after treatment with angiotensin II (By similarity). Shuttles between the cytoplasm and nucleus via its association with PDPK1. {ECO:0000250}.

Disease Associations

Tissue Specificity

Isoform 1 is expressed in hematopoietic cells. Isoform 2 is expressed in non-hematopoietic cells.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 169 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.

Experimentally validated
Total	169 [view]
Protein-Protein	161 [view]
Protein-DNA	8 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	20 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004725	protein tyrosine phosphatase activity
GO:0005001	transmembrane receptor protein tyrosine phosphatase activity
GO:0005515	protein binding
GO:0016791	phosphatase activity
GO:0019901	protein kinase binding

Biological Process

GO:0006470	protein dephosphorylation
GO:0006915	apoptotic process
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007596	blood coagulation
GO:0008283	cell proliferation
GO:0008284	positive regulation of cell proliferation
GO:0008285	negative regulation of cell proliferation
GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling
GO:0016311	dephosphorylation
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0019221	cytokine-mediated signaling pathway
GO:0030154	cell differentiation
GO:0031295	T cell costimulation
GO:0045087	innate immune response (InnateDB)
GO:0050732	negative regulation of peptidyl-tyrosine phosphorylation
GO:0050900	leukocyte migration
GO:0060333	interferon-gamma-mediated signaling pathway
GO:0060334	regulation of interferon-gamma-mediated signaling pathway
GO:0060337	type I interferon signaling pathway
GO:0060338	regulation of type I interferon-mediated signaling pathway
GO:0060397	JAK-STAT cascade involved in growth hormone signaling pathway
GO:0070372	regulation of ERK1 and ERK2 cascade
GO:2000045	regulation of G1/S transition of mitotic cell cycle

Cellular Component

GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0016020	membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000242 Protein-tyrosine phosphatase, receptor/non-receptor type
IPR000387 Protein-tyrosine/Dual specificity phosphatase
IPR000980 SH2 domain
IPR003595 Protein-tyrosine phosphatase, catalytic
IPR012152 Protein-tyrosine phosphatase, non-receptor type-6, -11
IPR029021 Protein-tyrosine phosphatase-like

PFAM

PF00102
PF00017
PF14633

PRINTS

PR00700
PR00401

PIRSF

PIRSF000929

SMART

SM00194
SM00252
SM00404

TIGRFAMs

Post-translational Modifications

Modification

Cross-References