Version 5.4
Homo sapiens Protein: ACSM4
Summary
InnateDB Protein IDBP-230694.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ACSM4
Protein Name acyl-CoA synthetase medium-chain family member 4
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000382349
InnateDB Gene IDBG-230692 (ACSM4)
Protein Structure
UniProt Annotation
Function Has medium-chain fatty acid:CoA ligase activity with broad substrate specificity (in vitro). Acts on acids from C(4) to C(11) and on the corresponding 3-hydroxy- and 2,3- or 3,4- unsaturated acids (in vitro) (By similarity). {ECO:0000250}.
Subcellular Localization Mitochondrion matrix {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004321 fatty-acyl-CoA synthase activity
GO:0005524 ATP binding
GO:0046872 metal ion binding
GO:0047760 butyrate-CoA ligase activity
Biological Process
GO:0006631 fatty acid metabolic process
GO:0006637 acyl-CoA metabolic process
GO:0008152 metabolic process
Cellular Component
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
Protein Structure and Domains
PDB ID
InterPro IPR000873 AMP-dependent synthetase/ligase
PFAM PF00501
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P0C7M7
PhosphoSite PhosphoSite-P0C7M7
TrEMBL
UniProt Splice Variant
Entrez Gene 341392
UniGene Hs.450804
RefSeq NP_001073923
HUGO HGNC:32016
OMIM 614360
CCDS CCDS44825
HPRD
IMGT
EMBL AC131205 DY654856
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca