InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: HECTD1

Summary

InnateDB Protein

IDBP-230804.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HECTD1

Protein Name

HECT domain containing 1

Synonyms

EULIR;

Species

Homo sapiens

Ensembl Protein

ENSP00000382269

InnateDB Gene

IDBG-4370 (HECTD1)

Protein Structure

UniProt Annotation

Function

Probable E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. May be required for development of the head mesenchyme and neural tube closure (By similarity). {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.

Experimentally validated
Total	25 [view]
Protein-Protein	25 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005488	binding
GO:0005515	protein binding
GO:0016874	ligase activity
GO:0046872	metal ion binding

Biological Process

GO:0001843	neural tube closure
GO:0016567	protein ubiquitination
GO:0042787	protein ubiquitination involved in ubiquitin-dependent protein catabolic process

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR000569 HECT
IPR002110 Ankyrin repeat
IPR008979 Galactose-binding domain-like
IPR010606 Mib-herc2
IPR012919 Sad1/UNC-like, C-terminal
IPR016024 Armadillo-type fold
IPR020683 Ankyrin repeat-containing domain

PFAM