InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: EOMES

Summary

InnateDB Protein

IDBP-23121.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EOMES

Protein Name

eomesodermin

Synonyms

TBR2;

Species

Homo sapiens

Ensembl Protein

ENSP00000295743

InnateDB Gene

IDBG-23119 (EOMES)

Protein Structure

UniProt Annotation

Function

Functions as a transcriptional activator playing a crucial role during development. Functions in trophoblast differentiation and later in gastrulation, regulating both mesoderm delamination and endoderm specification. Plays a role in brain development being required for the specification and the proliferation of the intermediate progenitor cells and their progeny in the cerebral cortex. Also involved in the differentiation of CD8+ T-cells during immune response regulating the expression of lytic effector genes. {ECO:0000269PubMed:17353897, ECO:0000269PubMed:17566017}.

Subcellular Localization

Nucleus {ECO:0000305}.

Disease Associations

Note=A translocation t(3;10)(p24;q23) located 215 kb 3' to the EOMES gene but leading to loss of its expression was identified in a large consanguineous family. Homozygous silencing produces microcephaly associated with corpus callosum agenesis, bilateral polymicrogyria, ventricular dilatation and a small cerebellum.

Tissue Specificity

Expressed in CD8+ T-cells. {ECO:0000269PubMed:17566017}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001102	RNA polymerase II activating transcription factor binding
GO:0001191	RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001706	endoderm formation
GO:0001707	mesoderm formation
GO:0002302	CD8-positive, alpha-beta T cell differentiation involved in immune response
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007420	brain development
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0060706	cell differentiation involved in embryonic placenta development
GO:0060809	mesodermal to mesenchymal transition involved in gastrulation