InnateDB Protein
|
IDBP-23124.6
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
EIF3C
|
Protein Name
|
eukaryotic translation initiation factor 3, subunit C
|
Synonyms
|
eIF3-p110; EIF3CL; EIF3S8;
|
Species
|
Homo sapiens
|
Ensembl Protein
|
ENSP00000332604
|
InnateDB Gene
|
IDBG-23122 (EIF3C)
|
Protein Structure
|
|
Function |
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation.
|
Subcellular Localization |
Cytoplasm {ECO:0000255HAMAP-Rule:MF_03002}.
|
Disease Associations |
|
Tissue Specificity |
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 124 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
124
[view]
|
Protein-Protein |
122
[view]
|
Protein-DNA |
1
[view]
|
Protein-RNA |
0
|
DNA-DNA |
1
[view]
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
Predicted by orthology |
Total |
1 [view]
|
|
|
Molecular Function |
|
Biological Process |
|
Cellular Component |
|
PDB ID |
|
InterPro |
IPR000717
Proteasome component (PCI) domain
IPR008905
Eukaryotic translation initiation factor 3 subunit C, N-terminal domain
|
PFAM |
PF01399
PF05470
|
PRINTS |
|
PIRSF |
|
SMART |
SM00088
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q99613
|
PhosphoSite |
PhosphoSite-Q99613
|
TrEMBL |
H3BTY8
|
UniProt Splice Variant |
|
Entrez Gene |
8663
|
UniGene |
Hs.661687
|
RefSeq |
|
HUGO |
HGNC:3279
|
OMIM |
603916
|
CCDS |
CCDS10638
|
HPRD |
04889
|
IMGT |
|
EMBL |
AC002544
AC145285
AK000739
AK055366
AK292155
AK301183
BC000533
BC001571
BC071705
BC157842
BC157849
BT007335
CH878380
U46025
U91326
|
GenPept |
AAC27426
AAC27674
AAD03462
AAH00533
AAH01571
AAH71705
AAI57843
AAI57850
AAP35999
BAA91352
BAF84844
BAG51506
BAG62767
EAW50492
EAW50493
EAW50494
EAW50495
EAW50496
|
|
|