Version 5.4
Homo sapiens Protein: STOX1
Summary
InnateDB Protein IDBP-231300.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol STOX1
Protein Name storkhead box 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000382118
InnateDB Gene IDBG-76193 (STOX1)
Protein Structure
UniProt Annotation
Function
Subcellular Localization Isoform A: Cytoplasm. Nucleus. Note=Either found in the cytoplasm or in the nucleus. Nuclear expression of isoform A seems to be restricted to polyploid trophoblast cells.Isoform B: Nucleus.Isoform C: Nucleus, nucleolus.
Disease Associations Pre-eclampsia/eclampsia 4 (PEE4) [MIM:609404]: A hypertensive disorder of pregnancy characterized by new hypertension (blood pressure 140/90 or greater) presenting after 20 weeks' gestation with clinically relevant proteinuria. It impacts 2 individuals, the mother and her child, both of whom can be severely affected. Preeclampsia is one of the causes of maternal mortality and morbidity worldwide. {ECO:0000269PubMed:15806103}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 2 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
Biological Process
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR019391 Storkhead-box protein, winged-helix domain
PFAM PF10264
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6ZVD7
PhosphoSite PhosphoSite-Q6ZVD7
TrEMBL
UniProt Splice Variant
Entrez Gene 219736
UniGene Hs.37636
RefSeq NP_001123631
HUGO HGNC:23508
OMIM 609397
CCDS CCDS44417
HPRD 18579
IMGT
EMBL AK057864 AK057891 AK124681 AK127878 AL359844 AL391539 AY842014 AY842015 AY842016 AY842017 BC063627 BC140011 DQ099680
GenPept AAH63627 AAI40012 AAW48524 AAW48525 AAW48526 AAW48527 AAZ07992 BAB71600 BAB71607 BAC85925 BAC87173 CAQ07951 CAQ07952 CAQ07953 CAQ08406 CAQ08407 CAQ08408

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca