InnateDB Protein
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IDBP-231733.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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MED18
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Protein Name
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mediator complex subunit 18
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000381963
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InnateDB Gene
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IDBG-95201 (MED18)
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Protein Structure
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Function |
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
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Subcellular Localization |
Nucleus {ECO:0000305}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 61 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
61
[view]
|
Protein-Protein |
60
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
Accession |
GO Term |
GO:0001104
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RNA polymerase II transcription cofactor activity
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GO:0005515
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protein binding
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Biological Process |
GO:0006357
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regulation of transcription from RNA polymerase II promoter
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GO:0006366
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transcription from RNA polymerase II promoter
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Cellular Component |
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PDB ID |
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InterPro |
IPR019095
Mediator complex, subunit Med18, metazoa/fungi
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PFAM |
PF09637
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9BUE0
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PhosphoSite |
PhosphoSite-Q9BUE0
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TrEMBL |
B4DJL3
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UniProt Splice Variant |
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Entrez Gene |
54797
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UniGene |
Hs.479911
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RefSeq |
XP_003846798
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HUGO |
HGNC:25944
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OMIM |
612384
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CCDS |
CCDS322
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HPRD |
17476
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IMGT |
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EMBL |
AB107222
AK000052
AK296130
AL353622
BC002694
CH471059
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GenPept |
AAH02694
BAA90910
BAD06869
BAG58875
CAI19132
EAX07699
EAX07700
EAX07702
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