InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CRK

Summary

InnateDB Protein

IDBP-231803.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CRK

Protein Name

v-crk sarcoma virus CT10 oncogene homolog (avian)

Synonyms

CRKII; p38;

Species

Homo sapiens

Ensembl Protein

ENSP00000381942

InnateDB Gene

IDBG-14664 (CRK)

Protein Structure

UniProt Annotation

Function

The Crk-I and Crk-II forms differ in their biological activities. Crk-II has less transforming activity than Crk-I. Crk- II mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling. {ECO:0000269PubMed:11870224, ECO:0000269PubMed:1630456, ECO:0000269PubMed:17515907}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}. Note=Translocated to the plasma membrane upon cell adhesion. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 216 experimentally validated interaction(s) in this database.
They are also associated with 31 interaction(s) predicted by orthology.

Experimentally validated
Total	216 [view]
Protein-Protein	216 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	31 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0042169	SH2 domain binding
GO:0046875	ephrin receptor binding

Biological Process

GO:0000186	activation of MAPKK activity
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0007596	blood coagulation
GO:0008286	insulin receptor signaling pathway
GO:0030168	platelet activation
GO:0032319	regulation of Rho GTPase activity
GO:0032956	regulation of actin cytoskeleton organization
GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0045087	innate immune response
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0048013	ephrin receptor signaling pathway