Homo sapiens Protein: ERG | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Protein | IDBP-231912.6 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | ERG | ||||||||||||||||||||||
Protein Name | v-ets erythroblastosis virus E26 oncogene homolog (avian) | ||||||||||||||||||||||
Synonyms | erg-3; p55; | ||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||
Ensembl Protein | ENSP00000381891 | ||||||||||||||||||||||
InnateDB Gene | IDBG-3269 (ERG) | ||||||||||||||||||||||
Protein Structure | |||||||||||||||||||||||
UniProt Annotation | |||||||||||||||||||||||
Function | Transcriptional regulator. May participate in transcriptional regulation through the recruitment of SETDB1 histone methyltransferase and subsequent modification of local chromatin structure. | ||||||||||||||||||||||
Subcellular Localization | Nucleus {ECO:0000255PROSITE- ProRule:PRU00237, ECO:0000269PubMed:17289661}. Cytoplasm {ECO:0000269PubMed:17289661}. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. | ||||||||||||||||||||||
Disease Associations | Ewing sarcoma (ES) [MIM:612219]: A highly malignant, metastatic, primitive small round cell tumor of bone and soft tissue that affects children and adolescents. It belongs to the Ewing sarcoma family of tumors, a group of morphologically heterogeneous neoplasms that share the same cytogenetic features. They are considered neural tumors derived from cells of the neural crest. Ewing sarcoma represents the less differentiated form of the tumors. Note=The gene represented in this entry is involved in disease pathogenesis. A chromosomal aberration involving ERG has been found in patients with Erwing sarcoma. Translocation t(21;22)(q22;q12) with EWSR1.Note=Chromosomal aberrations involving ERG have been found in acute myeloid leukemia (AML). Translocation t(16;21)(p11;q22) with FUS. Translocation t(X;21)(q25-26;q22) with ELF4. | ||||||||||||||||||||||
Tissue Specificity | |||||||||||||||||||||||
Comments | |||||||||||||||||||||||
Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 151 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||||||||
PDB ID | |||||||||||||||||||||||
InterPro |
IPR000418
Ets domain IPR003118 Pointed domain IPR013761 Sterile alpha motif/pointed domain |
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PFAM |
PF00178
PF02198 |
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PRINTS |
PR00454
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PIRSF | |||||||||||||||||||||||
SMART |
SM00413
SM00251 |
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TIGRFAMs | |||||||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||||||
Modification | |||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||
SwissProt | P11308 | ||||||||||||||||||||||
PhosphoSite | PhosphoSite-P11308 | ||||||||||||||||||||||
TrEMBL | Q16031 | ||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | 2078 | ||||||||||||||||||||||
UniGene | Hs.473819 | ||||||||||||||||||||||
RefSeq | NP_001230357 | ||||||||||||||||||||||
HUGO | HGNC:3446 | ||||||||||||||||||||||
OMIM | 165080 | ||||||||||||||||||||||
CCDS | CCDS46648 | ||||||||||||||||||||||
HPRD | 01298 | ||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
EMBL | AF015313 AK300395 AK301277 AK303518 AY204741 AY204742 BC040168 M17254 M21535 S68130 | ||||||||||||||||||||||
GenPept | AAA35811 AAA52398 AAB29724 AAB65763 AAH40168 AAP41719 AAP41720 BAG62127 BAG62837 BAG64546 | ||||||||||||||||||||||