InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PDS5B

Summary

InnateDB Protein

IDBP-23235.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PDS5B

Protein Name

PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)

Synonyms

APRIN; AS3; CG008;

Species

Homo sapiens

Ensembl Protein

ENSP00000313851

InnateDB Gene

IDBG-23233 (PDS5B)

Protein Structure

UniProt Annotation

Function

Regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Plays a role in androgen-induced proliferative arrest in prostate cells. {ECO:0000269PubMed:10963680, ECO:0000269PubMed:15855230, ECO:0000269PubMed:19696148}.

Subcellular Localization

Nucleus {ECO:0000250UniProtKB:Q6TRW4}.

Disease Associations

Tissue Specificity

Widely expressed. {ECO:0000269PubMed:9459187}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 35 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	35 [view]
Protein-Protein	35 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0005488	binding
GO:0005515	protein binding
GO:0005524	ATP binding

Biological Process

GO:0000278	mitotic cell cycle
GO:0007064	mitotic sister chromatid cohesion
GO:0008283	cell proliferation
GO:0008285	negative regulation of cell proliferation
GO:0042127	regulation of cell proliferation