Version 5.4
Homo sapiens Protein: FAM3B
Summary
InnateDB Protein IDBP-232545.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FAM3B
Protein Name family with sequence similarity 3, member B
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000381642
InnateDB Gene IDBG-3894 (FAM3B)
Protein Structure
UniProt Annotation
Function Induces apoptosis of alpha and beta cells in a dose- and time-dependent manner. {ECO:0000269PubMed:16114871}.
Subcellular Localization Secreted. Note=Present in insulin secretory granules and likely cosecreted with insulin. Localized in discrete vesicular and perinuclear structure.
Disease Associations
Tissue Specificity Highly expressed in the pancreas. Also found in the colon, kidney, prostate, small intestine and testis. {ECO:0000269PubMed:16114871}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005125 cytokine activity
Biological Process
GO:0006915 apoptotic process
GO:0030073 insulin secretion
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P58499
PhosphoSite PhosphoSite-P58499
TrEMBL
UniProt Splice Variant
Entrez Gene 54097
UniGene Hs.736846
RefSeq NP_996847
HUGO HGNC:1253
OMIM 608617
CCDS CCDS42930
HPRD 10552
IMGT
EMBL AF375989 AF494379 AJ409094 AY040086 AY358459 BC057829
GenPept AAH57829 AAK74134 AAL34495 AAM94280 AAQ88824 CAC83974

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca