InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SFTPA1

Summary

InnateDB Protein

IDBP-232576.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SFTPA1

Protein Name

surfactant protein A1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000381633

InnateDB Gene

IDBG-80144 (SFTPA1)

Protein Structure

UniProt Annotation

Function

In presence of calcium ions, it binds to surfactant phospholipids and contributes to lower the surface tension at the air-liquid interface in the alveoli of the mammalian lung and is essential for normal respiration.

Subcellular Localization

Secreted, extracellular space, extracellular matrix. Secreted, extracellular space, surface film.

Disease Associations

Pulmonary fibrosis, idiopathic (IPF) [MIM:178500]: A lung disease characterized by shortness of breath, radiographically evident diffuse pulmonary infiltrates, and varying degrees of inflammation and fibrosis on biopsy. In some cases, the disorder can be rapidly progressive and characterized by sequential acute lung injury with subsequent scarring and end-stage lung disease. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.Respiratory distress syndrome in premature infants (RDS) [MIM:267450]: A lung disease affecting usually premature newborn infants. It is characterized by deficient gas exchange, diffuse atelectasis, high-permeability lung edema and fibrin-rich alveolar deposits called 'hyaline membranes'. {ECO:0000269PubMed:10762543}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry. The association between SFTPA1 alleles and respiratory distress syndrome in premature infants is dependent on a variation Ile to Thr at position 131 in SFTPB.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.