InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GSTP1

Summary

InnateDB Protein

IDBP-232672.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GSTP1

Protein Name

glutathione S-transferase pi 1

Synonyms

DFN7; FAEES3; GST3; GSTP; HEL-S-22; PI;

Species

Homo sapiens

Ensembl Protein

ENSP00000381607

InnateDB Gene

IDBG-60718 (GSTP1)

Protein Structure

UniProt Annotation

Function

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration. {ECO:0000269PubMed:21668448}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:19269317}. Mitochondrion {ECO:0000269PubMed:19269317}. Nucleus {ECO:0000269PubMed:19269317}. Note=The 83 N-terminal amino acids function as un uncleaved transit peptide, and arginine residues within it are crucial for mitochondrial localization.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 41 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	41 [view]
Protein-Protein	37 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004364	glutathione transferase activity
GO:0005515	protein binding
GO:0008432	JUN kinase binding
GO:0019207	kinase regulator activity
GO:0035730	S-nitrosoglutathione binding
GO:0035731	dinitrosyl-iron complex binding
GO:0070026	nitric oxide binding

Biological Process

GO:0000302	response to reactive oxygen species
GO:0002674	negative regulation of acute inflammatory response
GO:0006469	negative regulation of protein kinase activity
GO:0006749	glutathione metabolic process
GO:0006805	xenobiotic metabolic process
GO:0007417	central nervous system development
GO:0009890	negative regulation of biosynthetic process
GO:0010804	negative regulation of tumor necrosis factor-mediated signaling pathway
GO:0032691	negative regulation of interleukin-1 beta production
GO:0032720	negative regulation of tumor necrosis factor production
GO:0032872	regulation of stress-activated MAPK cascade
GO:0032873	negative regulation of stress-activated MAPK cascade
GO:0032930	positive regulation of superoxide anion generation
GO:0035726	common myeloid progenitor cell proliferation
GO:0035732	nitric oxide storage
GO:0043066	negative regulation of apoptotic process
GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043407	negative regulation of MAP kinase activity
GO:0043409	negative regulation of MAPK cascade
GO:0043508	negative regulation of JUN kinase activity
GO:0044281	small molecule metabolic process
GO:0045087	innate immune response (InnateDB)
GO:0048147	negative regulation of fibroblast proliferation
GO:0051771	negative regulation of nitric-oxide synthase biosynthetic process
GO:0070372	regulation of ERK1 and ERK2 cascade
GO:0070373	negative regulation of ERK1 and ERK2 cascade
GO:0070664	negative regulation of leukocyte proliferation
GO:0071222	cellular response to lipopolysaccharide
GO:0071638	negative regulation of monocyte chemotactic protein-1 production
GO:1901687	glutathione derivative biosynthetic process
GO:2001237	negative regulation of extrinsic apoptotic signaling pathway

Cellular Component

GO:0005615	extracellular space
GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0070062	extracellular vesicular exosome
GO:0097057	TRAF2-GSTP1 complex

Protein Structure and Domains

PDB ID

InterPro

IPR003082 Glutathione S-transferase, Pi class
IPR004045 Glutathione S-transferase, N-terminal
IPR004046 Glutathione S-transferase, C-terminal
IPR010987 Glutathione S-transferase, C-terminal-like
IPR012336 Thioredoxin-like fold

PFAM