InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: LCP1

Summary

InnateDB Protein

IDBP-232734.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LCP1

Protein Name

lymphocyte cytosolic protein 1 (L-plastin)

Synonyms

CP64; HEL-S-37; L-PLASTIN; LC64P; LPL; PLS2;

Species

Homo sapiens

Ensembl Protein

ENSP00000381581

InnateDB Gene

IDBG-30382 (LCP1)

Protein Structure

UniProt Annotation

Function

Actin-binding protein. Plays a role in the activation of T-cells in response to costimulation through TCR/CD3 and CD2 or CD28. Modulates the cell surface expression of IL2RA/CD25 and CD69. {ECO:0000269PubMed:16636079, ECO:0000269PubMed:17294403}.

Subcellular Localization

Cytoplasm, cytoskeleton. Cell junction. Cell projection. Cell projection, ruffle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Relocalizes to the immunological synapse between peripheral blood T-lymphocytes and antibody-presenting cells in response to costimulation through TCR/CD3 and CD2 or CD28. Associated with the actin cytoskeleton at membrane ruffles (By similarity). Relocalizes to actin-rich cell projections upon serine phosphorylation. {ECO:0000250}.

Disease Associations

Note=Chromosomal aberrations involving LCP1 is a cause of B-cell non-Hodgkin lymphomas (B-cell NHL). Translocation t(3;13)(q27;q14), with BCL6.

Tissue Specificity

Detected in intestinal microvilli, hair cell stereocilia, and fibroblast filopodia, in spleen and other lymph node-containing organs. Expressed in peripheral blood T- lymphocytes, neutrophils, monocytes, B-lymphocytes, and myeloid cells. {ECO:0000269PubMed:3261603}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	12 [view]
Protein-Protein	12 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0042802	identical protein binding
GO:0051015	actin filament binding

Biological Process

GO:0002286	T cell activation involved in immune response
GO:0010737	protein kinase A signaling
GO:0016477	cell migration
GO:0031100	organ regeneration
GO:0033157	regulation of intracellular protein transport
GO:0051017	actin filament bundle assembly

Cellular Component

GO:0001725	stress fiber
GO:0001726	ruffle
GO:0001891	phagocytic cup
GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005884	actin filament
GO:0005886	plasma membrane
GO:0005925	focal adhesion
GO:0015629	actin cytoskeleton
GO:0030175	filopodium
GO:0032432	actin filament bundle
GO:0032587	ruffle membrane
GO:0070062	extracellular vesicular exosome