InnateDB Protein
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IDBP-232910.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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DPYSL3
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Protein Name
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dihydropyrimidinase-like 3
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Synonyms
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CRMP-4; CRMP4; DRP-3; DRP3; LCRMP; ULIP; ULIP-1;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000381526
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InnateDB Gene
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IDBG-52219 (DPYSL3)
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Protein Structure
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Function |
Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cytoplasm {ECO:0000250}. Cell projection, growth cone {ECO:0000250}. Note=Colocalizes with synaptic vesicle protein 2 in the central region of the growth cone. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Mainly expressed in heart and skeletal muscle. Also strongly expressed in fetal brain and spinal cord.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated |
Total |
19
[view]
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Protein-Protein |
17
[view]
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Protein-DNA |
2
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
2 [view]
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|
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Molecular Function |
Accession |
GO Term |
GO:0016787
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hydrolase activity
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GO:0016810
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hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
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GO:0016812
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hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
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GO:0017124
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SH3 domain binding
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GO:0035374
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chondroitin sulfate binding
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR006680
Amidohydrolase 1
IPR011059
Metal-dependent hydrolase, composite domain
IPR011778
Hydantoinase/dihydropyrimidinase
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PFAM |
PF01979
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q14195
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PhosphoSite |
PhosphoSite-Q14195
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TrEMBL |
F5GWI3
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UniProt Splice Variant |
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Entrez Gene |
1809
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UniGene |
Hs.519659
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RefSeq |
NP_001378
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HUGO |
HGNC:3015
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OMIM |
601168
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CCDS |
CCDS43381
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HPRD |
03104
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IMGT |
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EMBL |
AC011373
D78014
EU007906
Y07818
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GenPept |
ABV80252
BAA11192
CAA69153
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