InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SLC26A1

Summary

InnateDB Protein

IDBP-232916.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC26A1

Protein Name

solute carrier family 26 (sulfate transporter), member 1

Synonyms

EDM4; SAT-1; SAT1;

Species

Homo sapiens

Ensembl Protein

ENSP00000381528

InnateDB Gene

IDBG-6286 (SLC26A1)

Protein Structure

UniProt Annotation

Function

High affinity uptake of sulfate. Accepts oxalate, but not succinate as a cosubstrate. Mediates sulfate and oxalate transport. {ECO:0000269PubMed:12713736}.

Subcellular Localization

Membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed most abundantly in the kidney and liver, with lower levels in the pancreas, testis, brain, small intestine, colon, and lung. {ECO:0000269PubMed:12713736}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008271	secondary active sulfate transmembrane transporter activity
GO:0015108	chloride transmembrane transporter activity
GO:0015116	sulfate transmembrane transporter activity
GO:0015301	anion:anion antiporter activity
GO:0019531	oxalate transmembrane transporter activity

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0006805	xenobiotic metabolic process
GO:0006811	ion transport
GO:0006821	chloride transport
GO:0008272	sulfate transport
GO:0019532	oxalate transport
GO:0030203	glycosaminoglycan metabolic process
GO:0044281	small molecule metabolic process
GO:0050427	3'-phosphoadenosine 5'-phosphosulfate metabolic process
GO:0050428	3'-phosphoadenosine 5'-phosphosulfate biosynthetic process
GO:0055085	transmembrane transport
GO:1902358	sulfate transmembrane transport
GO:1902476	chloride transmembrane transport