Version 5.4
Homo sapiens Protein: NOTO
Summary
InnateDB Protein IDBP-233025.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NOTO
Protein Name notochord homeobox
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000381486
InnateDB Gene IDBG-233023 (NOTO)
Protein Structure
UniProt Annotation
Function Transcription regulator acting downstream of both FOXA2 and T during notochord development. Required for node morphogenesis. Is essential for cilia formation in the posterior notochord (PNC) and for left-right patterning; acts upstream of FOXJ1 and RFX3 in this process and is required for the expression of various components important for axonemal assembly and function. Plays a role in regulating axial versus paraxial cell fate (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000255PROSITE- ProRule:PRU00108}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007368 determination of left/right symmetry
GO:0009880 embryonic pattern specification
GO:0009953 dorsal/ventral pattern formation
GO:0030903 notochord development
GO:0060271 cilium morphogenesis
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro IPR001356 Homeobox domain
IPR009057 Homeodomain-like
PFAM PF00046
PRINTS
PIRSF
SMART SM00389
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt A8MTQ0
PhosphoSite PhosphoSite-A8MTQ0
TrEMBL
UniProt Splice Variant
Entrez Gene 344022
UniGene Hs.694384
RefSeq NP_001127934
HUGO HGNC:31839
OMIM
CCDS CCDS46335
HPRD
IMGT
EMBL AC010913 AK295936 AK316410
GenPept BAG58721 BAH14781

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca