Version 5.4
Homo sapiens Protein: DTX2
Summary
InnateDB Protein IDBP-23313.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DTX2
Protein Name Protein deltex-2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000322885
InnateDB Gene IDBG-23309 (DTX2)
Protein Structure
UniProt Annotation
Function Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Functions as a ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:11564735}. Nucleus {ECO:0000269PubMed:11564735}. Note=Predominantly cytoplasmic. Partially nuclear.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 25 [view]
Protein-Protein 25 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
Biological Process
GO:0007219 Notch signaling pathway
GO:0016567 protein ubiquitination
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0031965 nuclear membrane
Protein Structure and Domains
PDB ID
InterPro IPR001841 Zinc finger, RING-type
IPR004170 WWE domain
IPR018123 WWE domain, subgroup
PFAM PF13639
PF14634
PF02825
PRINTS
PIRSF
SMART SM00184
SM00678
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q86UW9
PhosphoSite PhosphoSite-Q86UW9
TrEMBL Q75MM6
UniProt Splice Variant
Entrez Gene 113878
UniGene Hs.187058
RefSeq NP_065943
HUGO HGNC:15973
OMIM 613141
CCDS CCDS5587
HPRD 16841
IMGT
EMBL AB040961 AC005522 AC007078 AK023924 AY225124 AY225125 BC008856 BC018555 BC026059 BC093079 DQ082730
GenPept AAH08856 AAH18555 AAH26059 AAH93079 AAP21881 AAP57518 AAP57519 AAS07525 AAZ06435 BAA96052 BAB14727

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca