InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CABIN1

Summary

InnateDB Protein

IDBP-233334.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CABIN1

Protein Name

calcineurin binding protein 1

Synonyms

CAIN; PPP3IN;

Species

Homo sapiens

Ensembl Protein

ENSP00000381364

InnateDB Gene

IDBG-2725 (CABIN1)

Protein Structure

UniProt Annotation

Function

May be required for replication-independent chromatin assembly. May serve as a negative regulator of T-cell receptor (TCR) signaling via inhibition of calcineurin. Inhibition of activated calcineurin is dependent on both PKC and calcium signals. Acts as a negative regulator of p53/TP53 by keeping p53 in an inactive state on chromatin at promoters of a subset of it's target genes. {ECO:0000269PubMed:14718166, ECO:0000269PubMed:9655484}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:9655484}.

Disease Associations

Tissue Specificity

Widely expressed in different tissues. {ECO:0000269PubMed:9655484}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	31 [view]
Protein-Protein	31 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004864	protein phosphatase inhibitor activity
GO:0005515	protein binding

Biological Process

GO:0006336	DNA replication-independent nucleosome assembly
GO:0007166	cell surface receptor signaling pathway
GO:0016568	chromatin modification
GO:0043086	negative regulation of catalytic activity