Homo sapiens Protein: STARD13
Summary
InnateDB Protein IDBP-23342.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol STARD13
Protein Name StAR-related lipid transfer (START) domain containing 13
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000338785
InnateDB Gene IDBG-23340 (STARD13)
Protein Structure
UniProt Annotation
Function GTPase-activating protein for RhoA, and perhaps for Cdc42. May be involved in regulation of cytoskeletal reorganization, cell proliferation and cell motility. Acts a tumor suppressor in hepatocellular carcinoma cells. {ECO:0000269PubMed:14697242, ECO:0000269PubMed:16217026}.
Subcellular Localization Cytoplasm. Membrane; Peripheral membrane protein; Cytoplasmic side. Mitochondrion membrane; Peripheral membrane protein; Cytoplasmic side. Lipid droplet.
Disease Associations
Tissue Specificity Ubiquitously expressed. Underexpressed in hepatocellular carcinoma cells and some breast cancer cell lines. {ECO:0000269PubMed:12531887, ECO:0000269PubMed:14697242}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
Experimentally validated
Total 26 [view]
Protein-Protein 24 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005096 GTPase activator activity
GO:0005515 protein binding
GO:0008289 lipid binding
Biological Process
GO:0007165 signal transduction
GO:0007264 small GTPase mediated signal transduction
GO:0043547 positive regulation of GTPase activity
GO:0051056 regulation of small GTPase mediated signal transduction
Cellular Component
GO:0005622 intracellular
GO:0005811 lipid particle
GO:0005829 cytosol
GO:0031966 mitochondrial membrane
Protein Structure and Domains
PDB ID
InterPro IPR000198 Rho GTPase-activating protein domain
IPR002913 START domain
IPR008936 Rho GTPase activation protein
IPR011510 Sterile alpha motif, type 2
IPR013761 Sterile alpha motif/pointed domain
PFAM PF00620
PF01852
PF07647
PRINTS
PIRSF
SMART SM00324
SM00234
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9Y3M8
PhosphoSite PhosphoSite-Q9Y3M8
TrEMBL B3KT04
UniProt Splice Variant
Entrez Gene 90627
UniGene Hs.560163
RefSeq NP_821074
HUGO HGNC:19164
OMIM 609866
CCDS CCDS9348
HPRD 11607
IMGT
EMBL AK094704 AK312888 AL049801 AL139187 AL627232 AY082589 AY082590 AY082591 AY366448 BC046563 BX647695 CH471075 Z84483
GenPept AAH46563 AAL91648 AAL91649 AAL91650 AAQ72791 BAG35736 BAG52916 CAB42562 CAC94774 CAI46026 CAM17900 CAM23625 CAM23626 EAX08527 EAX08528 EAX08530