Version 5.4
Homo sapiens Protein: PPAPDC1A
Summary
InnateDB Protein IDBP-233561.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PPAPDC1A
Protein Name phosphatidic acid phosphatase type 2 domain containing 1A
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000381302
InnateDB Gene IDBG-91322 (PPAPDC1A)
Protein Structure
UniProt Annotation
Function Displays magnesium-independent phosphatidate phosphatase activity in vitro. Catalyzes the conversion of phosphatidic acid to diacylglycerol. {ECO:0000269PubMed:17590538}.
Subcellular Localization Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Disease Associations
Tissue Specificity Expressed mainly to the brain, kidney and testis, and to a lesser extent the bone marrow, thymus, prostate, liver and uterus. {ECO:0000269PubMed:17590538}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0008195 phosphatidate phosphatase activity
Biological Process
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0045087 innate immune response
GO:0046839 phospholipid dephosphorylation
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR000326 Phosphatidic acid phosphatase type 2/haloperoxidase
PFAM PF01569
PRINTS
PIRSF
SMART SM00014
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q5VZY2
PhosphoSite PhosphoSite-Q5VZY2
TrEMBL
UniProt Splice Variant
Entrez Gene 196051
UniGene Hs.40479
RefSeq NP_001025230
HUGO HGNC:23531
OMIM
CCDS CCDS41573
HPRD 18745
IMGT
EMBL AC023282 AC073587 AL157782 BC101267 BC101268 BC101269 BC122535 BC132787 BD418666
GenPept AAI01268 AAI01269 AAI01270 AAI22536 AAI32788 CAH70332 CAH70333

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca