Version 5.4
Homo sapiens Protein: RDH16
Summary
InnateDB Protein IDBP-233804.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RDH16
Protein Name retinol dehydrogenase 16 (all-trans)
Synonyms RODH-4; SDR9C8;
Species Homo sapiens
Ensembl Protein ENSP00000381206
InnateDB Gene IDBG-41713 (RDH16)
Protein Structure
UniProt Annotation
Function Oxidoreductase with a preference for NAD. Oxidizes all- trans-retinol and 13-cis-retinol to the corresponding aldehydes. Has higher activity towards CRBP-bound retinol than with free retinol. Oxidizes 3-alpha-hydroxysteroids. Oxidizes androstanediol and androsterone to dihydrotestosterone and androstanedione. Can also catalyze the reverse reaction. {ECO:0000269PubMed:10329026, ECO:0000269PubMed:12534290, ECO:0000269PubMed:9677409}.
Subcellular Localization Microsome membrane; Single-pass type IV membrane protein. Endoplasmic reticulum membrane {ECO:0000305}; Single-pass type IV membrane protein {ECO:0000305}.
Disease Associations
Tissue Specificity Highly expressed in adult liver (at protein level). Detected in endometrium, liver and foreskin. Detected in the spineous layers of adult skin, and at lower levels in basal and granular skin layers. Detected in fetal liver and lung. {ECO:0000269PubMed:10329026, ECO:0000269PubMed:11967490, ECO:0000269PubMed:9677409}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004745 retinol dehydrogenase activity
GO:0009055 electron carrier activity
GO:0016491 oxidoreductase activity
Biological Process
GO:0006629 lipid metabolic process
GO:0008152 metabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
GO:0043231 intracellular membrane-bounded organelle
Protein Structure and Domains
PDB ID
InterPro IPR002198 Short-chain dehydrogenase/reductase SDR
IPR002347 Glucose/ribitol dehydrogenase
PFAM PF00106
PRINTS PR00080
PR00081
PIRSF PIRSF000126
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O75452
PhosphoSite PhosphoSite-O75452
TrEMBL
UniProt Splice Variant
Entrez Gene 8608
UniGene Hs.134958
RefSeq NP_003699
HUGO HGNC:29674
OMIM
CCDS CCDS41797
HPRD 10208
IMGT
EMBL AF057034 AF086735
GenPept AAC39922 AAC72923

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca