InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CTDSP2

Summary

InnateDB Protein

IDBP-233924.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CTDSP2

Protein Name

CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2

Synonyms

OS4; PSR2; SCP2;

Species

Homo sapiens

Ensembl Protein

ENSP00000381148

InnateDB Gene

IDBG-44047 (CTDSP2)

Protein Structure

UniProt Annotation

Function

Preferentially catalyzes the dephosphorylation of 'Ser- 5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells. May contribute to the development of sarcomas. {ECO:0000269PubMed:12721286, ECO:0000269PubMed:15681389}.

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Expression is restricted to non-neuronal tissues. Highest expression in pancreas and lowest in liver. {ECO:0000269PubMed:15681389}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.

Experimentally validated
Total	7 [view]
Protein-Protein	5 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008420	CTD phosphatase activity
GO:0016791	phosphatase activity
GO:0046872	metal ion binding

Biological Process

GO:0006470	protein dephosphorylation
GO:0006987	activation of signaling protein activity involved in unfolded protein response
GO:0016311	dephosphorylation
GO:0030968	endoplasmic reticulum unfolded protein response
GO:0044267	cellular protein metabolic process